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https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2021.26.26.2100533
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We found that, for individuals 55 years and older, the benefits of distributing Vaxzevria largely outweighed the risks in a range of possible scenarios. In contrast, in young adults, the risks were similar or higher than the benefits. These conclusions were driven by the steep increase in the severity of infection with age [15] as well as the higher risk of TTS following vaccination in individualsyounger than50 years [12]. The vaccination of older individuals with Vaxzevria reduced the number of deaths in this age group due to both direct (i.e. vaccinated individuals have a lower probability of fatal outcome) and indirect protection (i.e. younger adults who play a substantial role in transmission will be vaccinated earlier, reducing the risk of infection in all age groups).


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