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Schamat toksyczności sars-cov-2 poprzez mechanizm ADE

https://www.nature.com/articles/s41564-020-00789-5

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

Antibody-based drugs and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being expe-dited through preclinical and clinical development. Data from the study of SARS-CoV and other respiratory viruses suggest that anti-SARS-CoV-2 antibodies could exacerbate COVID-19 through antibody-dependent enhancement (ADE). Previous respira-tory syncytial virus and dengue virus vaccine studies revealed human clinical safety risks related to ADE, resulting in failed vac-cine trials. Here, we describe key ADE mechanisms and discuss mitigation strategies for SARS-CoV-2 vaccines and therapies in development. We also outline recently published data to evaluate the risks and opportunities for antibody-based protection against SARS-CoV-2.NAtuRE MiCRoBioLogy | VOL 5 | OCTOBER 2020 | 1185–1191 | www.nature.com/naturemicrobiology1185
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