[ZapomnialWieprzJakProsiakiemByl]

Kolejny argument dlaczego ozdrowieńcy powinni się szczepić. Szczepionki mRNA podane ozdrowieńcom silnie podnoszą liczbę przeciwciał zdolnych neutralizować nowe warianty SARS-CoV-2 a nawet na SARS-CoV-1
https://science.sciencemag.org/content/early/2021/03/24/science.abg9175
Emerging SARS-CoV-2 variants have raised concerns about resistance to neutralizing antibodies elicited by previous infection or vaccination. We examined whether sera from recovered and naïve donors collected prior to, and following immunizations with existing mRNA vaccines, could neutralize the Wuhan-Hu-1 and B.1.351 variants. Pre-vaccination sera from recovered donors neutralized Wuhan-Hu-1 and sporadically neutralized B.1.351, but a single immunization boosted neutralizing titers against all variants and SARS-CoV-1 by up to 1000-fold. Neutralization was due to antibodies targeting the receptor binding domain and was not boosted by a second immunization. Immunization of naïve donors also elicited cross-neutralizing responses, but at lower titers. Our study highlights the importance of vaccinating both uninfected and previously infected persons to elicit cross-variant neutralizing antibodies.

Although the correlates of protection for SARS CoV-2 vaccines have not been established, studies in non-human primates indicate that even low titers of neutralizing antibodies are sufficient to prevent experimental SARS-CoV-2 infection, particularly if CD8+ T-cell responses are mounted (18).Our study suggests that most previously infected subjects will benefit from a single immunization with either the Pfizer/BioNTech or Moderna vaccines as it will lead to significant increases in serum neutralizing antibody responses against vaccine-matched and emerging variants. The observation that a second dose administered three to four weeks following the first in previously infected donors who have clear evidence of RBD-directed immunological memory prior to vaccination did not further boost neutralizing titers, suggests that the second dose of an mRNA vaccine could be delayed in some persons who have previously been infected with SARS-CoV-2. Longitudinal monitoring of the neutralizing antibody titers before and following the first dose should be used to determine the necessity, or optimal timing of the second dose in the context of previous infection.
https://science.sciencemag.org/content/early/2021/03/24/science.abg9175

#koronawirus #medycyna #szczepienia

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@ZapomnialWieprzJakProsiakiemByl idę w czwartek. Szwagier po fajzerze zdychał dwa dni. Jak będę mieć to samo, to swojego nopa przejdę gorzej niż covida.

[ZapomnialWieprzJakProsiakiemByl]

@Zona_faraona: mnie tylko ręka bolała. U wszystkich znajomych i rodziców też bez problemów i na bólu reki się skończyło:)
Trzymam kciuki żeby by ciebie nie sponiewierało. ( ͡° ͜ʖ ͡°)

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@ZapomnialWieprzJakProsiakiemByl sporo kryje się pod hasłem objawy grypopodobne.
Bratu nie było nic, babci (lvl 80) też. A pozostali coś tam narzekali, temperatura, ból głowy, nawet nudności.